BIX-01294 increases pig cloning efficiency by improving epigenetic reprogramming of somatic cell nuclei
نویسندگان
چکیده
منابع مشابه
TSA and BIX-01294 Induced Normal DNA and Histone Methylation and Increased Protein Expression in Porcine Somatic Cell Nuclear Transfer Embryos
The poor efficiency of animal cloning is mainly attributed to the defects in epigenetic reprogramming of donor cells' chromatins during early embryonic development. Previous studies indicated that inhibition of histone deacetylases or methyltransferase, such as G9A, using Trichostatin A (TSA) or BIX-01294 significantly enhanced the developmental efficiency of porcine somatic cell nuclear transf...
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ژورنال
عنوان ژورنال: REPRODUCTION
سال: 2016
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-15-0460